A research team from the Japan Advanced Institute of Science and Technology has discovered bacteria from frogs, newts, and lizards possessing anticancer effects. Through isolating, culturing, and directly administering individual bacterial strains the team was able to identify a microbe that can attack tumors. The research team, led by Prof. Eijiro Miyako, isolated 45 bacterial strains from the intestines of Japanese tree frogs (Dryophytes japonicus), Japanese fire belly newts (Cynops pyrrhogaster), and Japanese grass lizards (Takydromus tachydromoides). One of the isolated microbes, Ewingella Americana, showed the most promise: when given to a mouse with cancer, E. americana completely eliminated the tumor. After administration, E. americana multiplied approximately 3,000-fold within 24 hours, and T cells, B cells, and neutrophils surrounded the tumors. E. americana did not spread to normal organs. It had rapid blood clearance (undetectable at 24 hours), caused only a mild inflammatory response, and had no chronic toxicity during the 60-day extended observation. The team will continue testing this treatment on breast cancer and melanoma. To read the study published in Gut Microbes click here https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2599562#abstract